2017年11月2日木曜日

千葉大学時代の私の研究室の卒業生で日本曹達株式会社の研究所に勤務している岩佐孝男君が、アメリカのノースカロライナ州立大学のMichael Roe教授の研究室に留学中に行ったネオニコチノイド剤のミツバチに対する選択毒性の機構を解明して2004年にイギリスの学会誌 Crop Protection に発表した下記論文は世界中の多くの研究者に引用されています。
http://www.sciencedirect.com/science/article/pii/S0261219403002308#!
この度、あるジャーナリストから届いたこの論文に対するコメントに対して、Roe教授から返信をする前に共著者の私と岩佐君宛に何か言いたいことがあれば至急知らせるようにとのメールが届きました。
私は、ジャーナリストはえてして論文の都合のよい部分だけを引用して自分の主張の裏付けに利用する可能性があるし、実験室で求めたLD50(半数致死薬量)を野外に適用してネオニコチノイド剤単独や殺菌剤その他の薬剤との相乗効果で世界中のミチバチの減少の原因となっているというような事実と異なる報道をするとマイナスなので、実験室内のLD50と野外での毒性影響とは異なるということを強調しておくことが必要だという趣旨のコメントを返しておきました。Roe教授は自分も全く同意見だということで、ジャーナリストに送った回答を送ってくれました。
果たして、どういう記事になるやら・・。

R Roe mroe@ncsu.edu        
宛先 motoyama335 motoyama335@aol.com, Takao Iwasa takao.iwasa@gmail.com

I will respond in obvious way that we stand by our work.   Let me know asap if you have something to say.
 
---------- Forwarded message ----------
From: "Wendy Zukerman" <wendyz@gimletmedia.com>
Date: Oct 30, 2017 8:04 PM
Subject: Media Fact Check (Urgent!) to your honeybee study
To: <michael_roe@ncsu.edu>
Cc:
 
Dear Michael
My name is Wendy Zukerman and I'm the host of the podcast Science Vs. We are developing an episode on What's Killing The Bees? And would like to site your 2004 study: Mechanism for the differential toxicity of neonicotinoid insecticides in the honey bee, Apis mellifera
 
It found that neonics when combined with a fungicide could make neonics up to 1000 times more harmful to honeybees. But then in the "Cage Study" it found they were safe. Is this an accurate portrayal of your work?
 
Scientists found that when you combined neonics with another chemical that farmers use -- called a fungicide -- it was a dangerous combo. Some fungicides might make it tricky for the bee to eliminate neonics from their system…making the neonics more poisonous than usual. But scientists worked this out in a lab… And here’s where it gets sticky: when they tried giving the bees the chemical combo in a more realistic setting -- with lower doses -- they turned out to be “safe”.
 
Also! Have you, or any other teams around the world, replicated this study? 
Thank you very much,
Wendy

Wendy Zukerman
Host, Science Vs podcast, Gimlet Media
wendyz@gimletmedia.com
+1 917-724-4198

以下は私のコメントとそれに対するRoe教授の返信
宛先 motoyama335 motoyama335@aol.com
CC Takao Iwasa takao.iwasa@gmail.com

thanks for the comments; this is my interpretation of our research as well.  

On Tue, Oct 31, 2017 at 10:06 AM, <motoyama335@aol.com> wrote:

Dear Mike, 
It was good that I could see you during my stay in North Carolina.  Thank you for letting me borrow equipment to separate nematodes from wood chips I collected from dead pine trees.
As for the interpretation of the results published in the paper, I think it is important to emphasize that LD50 determined in laboratory condition simply indicates potential of toxicity of a chemical or synergism in combination with other chemical, and it does not necessarily indicate the effect in an actual field condition because toxicity in the field is subject to various factors such as stability of a chemical, degradation, adsoption by plant as well as soil organic matter, etc.  Otherwise, a journalist would interpret the data subjectively as a support to his or her pre-fixed story.  It would be a misinformation if the journalist tries to claim that neonicotinoids or neonicotinoids when combined with fungicide or other chemicals are causing the decrease in bee population in the world. 
The leathal effect of neonicotinoids (only five out of seven neonicotinoids) takes place only when they are applied carelessly and bees have direct contact with high concentration of the insecticides in the environment.  After learning this lesson, Japanese farmers started communicating with bee keepers so that they avoid placing bee hives near where toxic neonicotinoids were recently applied.  This practice successfully avoided the accidental contact between bees and toxic neonicotinopids and resulted in a significant reduction of loss of bee hives.
Regards,
Naoki


以下は、Roe教授がジャーナリストに送った回答
 From: R Roe <mroe@ncsu.edu>
Date: Tue, Oct 31, 2017 at 11:24 AM
Subject: Re: Media Fact Check (Urgent!) to your honeybee study
To: Wendy Zukerman <wendyz@gimletmedia.com>

thanks for the note.  
First note that the 1000 fold effect you reference is with thiacloprid while the field work you are referencing is with acetamprid.  These are two different insecticide compounds.
It can not be assumed that lab results apply to field use.  Once we learned from our studies of a potential issue of mixing a fungicide with a neonicotinoid in the lab relative to honey bee effects, the obvious next question was whether this would occur under a potential field situation.  The experimental design was establish a priori, without knowledge of the outcome of the research and in context of what was within the research capability of our laboratory and time frame of when the work needed to be completed with the goal of simulating as much as possible a field situation.  In the field there are many environmental factors that are different from the lab like the presence of plants, differences in bee physiology and behavior, differences in plant and microbial physiology, pesticide turnover and distribution, pesticide levels, temperature and humidity differences, sunlight effects, and more.  This is why lab results have to be tested in the field.  Lab work is often conducted first because it is easier to perform and less expensive than field work.  In the work conducted with acetamiprid we did not find an effect with the fungicide under the conditions of the assay as conducted in the field and described in the paper.  I have not followed the research in this area since my published research and can not answer the question, has this work been repeated; you will need to search the literature on this point.  
Hope this helps.  .  

午後から江戸川堤防にウォーキング/ジョギングに出かけました。日没が何時頃だろうと思っていましたら、16:38には夕焼け空になり、16:59には暗くなり始めました。